Clinical Studies

Use of Laser Light to Treat Certain Lesions in Standardbreds, L.S McKibbin DVM, & D Paraschak BSc., MA; Modern Veterinary Practice, March 1984, Sec. 3, p. 13

Biostimulation of Wound Healing by Lasers: Experimental Approaches in Animal Models and in Fibroblast Cultures, RP Abergel, MD; R Lyons, MD; J Castel, MS, R Dwyer. MD and Uitlo. MD, PhD; Harbor UCLA Medical Center. CA: J Dennatol. Surgery Oncol., 13:2 Feb. 1987

Effect of Helium-Neon and Infrared Laser Irradiation on Wound Healing in Rabbits, B Braverman, PhD; R McCarthy. Pharmd, A Lyankovich, MD; D Forde, BS, M Overfield, BS and M Bapna, PhD; Rush- Presbyterian-St. Luke's Medical Center; University of Illinois, Lasers in Surgery and Medicine 9:50-58 (1989)

The Effects of Low Energy Laser on Soft Tissue in Veterinary Medicine, LS McKibbin & R Downie; The Acupuncture Institute, Ontario Canada; J. Wiley & Sons

Effects of Low Energy Laser on Wound Healing In a Porcine Model, J Hunter, MD; L Leonard, MD; R Wilsom MD; G Snider, MD and J DLxon, MD; Department of Surgery, University of Utah Medical Center, Salt Lake City UT, Lasers in Surgery & Med. 3:285-290, 84

A Study of the Effects or Lasering of Chronic Bowed Tendons, Wheatley, LS McKibbin DVM, and DM Paraschak Bsc MA; Lasers in Surgery & Medicine, Vol. pp. 55-59 (1983) Sec 3

Low-Energy Laser Therapy: Controversies & Research Findings, Jeffrey R. Basford MD; Mayo Clinic; Lasers in Surgery and Medicine 9, pp. 1-5 (1989) Smith, Kendric C, The Photobiological Basis of Low Level Laser Radiation Therapy, Stanford University School of Medicine; Laser Therapy, Vol. 3, No. 1, Jan - Mar 1991

Clark, Sir Arthur, Beyond Gravity, National Geographic Jan. 7, 2001, p2-29. Reports that Dr. Harry T. Whelan of the University of Wisconsin Medical School has successfully treated wounds, third degree burns, and brain cancer with LEDs.

Marshall Space Flight Centre press release 00-336 (12-18-00). Read More. Describes how LEDs are being used to heal hard to heal wounds such as diabetic skin ulcers, serious burns, oral sores, and musculoskeletal training injuries.

Thomasson, TL, Effects of Skin-Contact Monochromatic Infrared Irradiation on Tendonitis, Capsulitis, and Myofascial Pain, J Neurological Orthopedic Medical Surgery (1996) 16:242-245.


There is an ever-growing number of studies that have been conducted on the uses of light therapy. Presently over 2,500 studies and a multitude of articles on the subject have proven its efficacy. Some of the research is specific, as in regard to how light therapy affects diabetic patients or how it can be used in sports medicine to treat tendinopathy. Other studies look at the effects of treatment on anti-aging, fractures, depression or as a component of cancer treatments.

Please click on the links to view the various research documents or websites:

The first article below is a good place to start:

Studies

Acts Like Morphine Without Addiction or Side Effects: The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release, Ferreira SH, Duarte ID, Lorenzetti BB; Eur J Pharmacol 1991 Aug 16;201:121-2. Restoration of Sensation: Restoration of Sensation, Reduced Pain, and Improved Balance in Subjects With Diabetic Peripheral Neuropathy, Leonard DR, Farooqi MH, Myers S, Joslin Center for Diabetes FL, The Journal of Clinical and Applied Research and Education Diabetes Care, 2004, 27:1, pp 168-172. Clark, Sir Arthur, Beyond Gravity, National Geographic Jan. 7, 2001, p2-29. Reports that Dr. Harry T. Whelan of the University of Wisconsin Medical School has successfully treated wounds, third degree burns, and brain cancer with LEDs. Nitric Oxide: 1. Murad, F. Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. The New England journal of medicine 355:2003–2011; 2006. 2. Culotta, E.; Kochland, D. E. J. NO news is good news (Molecule of the Year). Science 258:1862–1864; 1992.

Describes how LEDs are being used to heal hard to heal wounds such as diabetic skin ulcers, serious burns, oral sores, and musculoskeletal training injuries. Thomasson, TL, Effects of Skin-Contact Monochromatic Infrared Irradiation on Tendonitis, Capsulitis, and Myofascial Pain, J Neurological Orthopedic Medical  Surgery (1996) 16:242-245.

(LED Treat GWVI), Dept. of Veterans Affairs, 2015

, Godine Richard L.. Photomedicine and Laser Surgery. January 2014, 32(1): 1-2. doi:10.1089/pho.2013.9867.

, Lasers in Medical Science, March 2012, Vol 27, Issue 2, pp 453-458

, MOTOI ISHIGURO, KAZUO IKEDA and KATSURO TOMITA, Journal of Orthopaedic Science, (2010) 15:233–239 DOI 10.1007/s00776-009-1438-4

, Teresa Ryan and RKW Smith, IR Veterinary Journal, 2007; 60(5): 295–299. Brousseau L, Welch V, Wells G, deBie R, Gam A, Harman K, Morin M, Shea B, Tugwell P. The Cochrane Library. Vol. 4. Chichester: John Wiley and Sons; 2003. Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis (Cochrane review) Enwemeka CS. Attenuation and penetration of visible 632.8 nm and invisible infra-red 904 nm light in soft tissues. Laser Therapy Journal. 2003;13:16. Flemming K, Cullum N. The Cochrane Library. Vol. 4. Chichester, UK: John Wiley and Sons; 2003. Laser therapy for venous leg ulcers (Cochrane methodology review) Gur A, Cosut A, Sarac AJ, Cevik R, Nas K, Uyar A. Efficacy of different therapy regimes of low power laser in painful osteoarthritis of the knee: a double blind and randomised controlled trial. Lasers in Surgery and Medicine. 2003;33(5):330–338. doi: 10.1002/lsm.10236. Sharma R, Thukral A, Kumar S, Bhargava SK. Effect of low level lasers in de Quervains tenosynovitis – a prospective study with ultrasonographic assessment. Physiotherapy. 2002;88(12):714–775. doi: 10.1016/S0031-9406(05)60716-X. Baxter GD. In: Electrotherapy: Evidence-Based Practice. 11. Kitchen S, Bazin S, editor. London: Churchill Livingstone; 2002. Low-intensity laser therapy; pp. 171–190. Clark, Sir Arthur, Beyond Gravity, National Geographic Jan. 7, 2001, p2-29. Reports that Dr. Harry T. Whelan of the University of Wisconsin Medical School has successfully treated wounds, third degree burns, and brain cancer with LEDs. Ramey DW, Basford JR. Laser therapy in horses. Compendium on Continuing Education for the Practicing Veterinarian. 2000;22(3):263–272. Low J, Reed A. Electrotherapy Explained: principles and practice. 3. Oxford: Butterworth Heinemann; 2000. Marshall Space Flight Centre press release 00-336 (12-18-00). http://www.msfc.nasa.gov/. Describes how LEDs are being used to heal hard to heal wounds such as diabetic skin ulcers, serious burns, oral sores, and musculoskeletal training injuries. Lucroy MD, Edwards BF, Madewell BR. Low-intensity laser light-induced closure of a chronic wound in a dog. Veterinary Surgery. 1999;28:292–295. doi: 10.1053/jvet.1999.0292. Baxter GD. Laser therapy seminar, Royal College of Surgeons in Ireland. 1999. Kolarova H, Ditrichova D, Wagner J. Penetration of the laser light into the skin in vitro. Lasers in Surgery and Medicine. 1999;24:231–235. doi: 10.1002/(SICI)1096-9101(1999)24:3<231::AID-LSM8>3.0.CO;2-#. Petersen SL, Botes C, Olivier A, Guthrie AJ. The effect of low level laser therapy (LLLT) on wound healing in horses. Equine Veterinary Journal. 1999;31(3):228–231. doi: 10.1111/j.2042-3306.1999.tb03177.x. Chartered Society of Physiotherapy. Standards for the use of electrophysical modalities and guidance in their application. Chartered Society of Physiotherapy Information Resource Centre; 1998. Laser therapy; pp. 27–30. Photonic Acupuncture. M.App.Sc. Thesis, McLaren B.; RMIT, Melbourne 1996 Thomasson, TL, Effects of Skin-Contact Monochromatic Infrared Irradiation on Tendonitis, Capsulitis, and Myofascial Pain, J Neurological Orthopedic Medical  Surgery (1996) 16:242-245. De Bie R, Verhagen A, Lenssen T, de Vet R, van den Wildenberg F. The Cochrane Library. Chichester: John Wiley and Sons; 1996. Oral presentation: Efficacy of 904 nm laser therapy in musculoskeletal disorders: a systematic review. Saunders L. The efficacy of low level laser therapy in supraspinatus tendonitis. Clinical Rehabilitation. 1995;9:126–134. doi: 10.1177/026921559500900207. Effects of Skin-Contact Monochromatic Infrared Irradiation on Tendonitis, Capsulitis and Myofascial Pain, T.L Thomassoi DDS, 19th Annual Scientific Meeting, American Academy of Neurological & Orthopaedic Surgeons, Aug. 27-30, 1995 Facial Pain/TMJ Centre, Denver, CO Baxter GD. Therapeutic Lasers, Theory and Practice. 1. New York: Churchill Livingstone; 1994. Lasers and Wound Healing, Albert J. Nemeth, MD; Laser and Dermatology Center, Clearwater FL, Dermatologic Clinics, Vol.. 11 #4, 1993 Gam AN, Thorsen H, Lonnberg F. The effect of low level laser therapy on musculoskeletal pain: a meta-analysis. Pain. 1993;53:63–66. doi: 10.1016/0304-3959(93)90114-5. Marr CM, Love JS, Boyd Q, McKellar Q. Factors affecting the clinical outcome of injuries to the superficial digital flexor tendon in National Hunt and point-to-point racehorses. The Veterinary Record. 1993;132:476–479. doi: 10.1136/vr.132.19.476. Bromiley M. Equine Injury, Therapy and Rehabilitation. 2. Oxford: Blackwell Science; 1993. Vasseljen O, Hoeg N, Kjeldstad B, Johnsson A, Larsen S. Low level laser versus placebo in the treatment of tennis elbow. Scandinavian Journal of Rehabilitation in Medicine. 1992;24:37–42. Fretz PB, Li Z. Low energy laser irradiation treatment for second intention wound healing in horses. Canadian Veterinary Journal. 1992;33:650–653. Low Level Laser Therapy as a Medical Treatment Modality. Pontinen P.; Tampere, Art Urpo Ltd. 1992 Honmura A, Yanase M, Obata J, Haruki E. Therapeutic effect of Ga-Al-As diode laser irradiation on experimentally induced inflammation in rats. Lasers in Surgery and Medicine. 1992;12:441–444. doi: 10.1002/lsm.1900120414. Beckerman H, de Bie RA, Bouter LM, De Cuyper HJ, Oostendorp RA. The efficacy of laser therapy for musculoskeletal and skin disorders: A criteria based meta-analysis of randomised clinical trials. Physical Therapy. 1992;72(7):483–491. Smith, Kendric C, The Photobiological Basis of Low Level Laser Radiation Therapy, Stanford University School of Medicine; Laser Therapy, Vol. 3, No. 1, Jan – Mar 1991 The Photobiological Basis of Low Level Laser Radiation Therapy, Kendric C. Smith; Stanford University School of Medicine; Laser Therapy, Vol. 3, No. 1, Jan – Mar 1991 Baxter GD, Bell AJ, Allen JM, Ravey J. Low level laser therapy: Current clinical practice in Northern Ireland. Physiotherapy. 1991;77(3):171–178. doi: 10.1016/S0031-9406(10)61696-3. Chartered Society of Physiotherapy. Guidelines for the safe use of lasers in physiotherapy. Physiotherapy. 1991;77(3):169–171. doi: 10.1016/S0031-9406(10)61695-1. Kitchen SS, Partridge CJ. A review of low level laser therapy. Physiotherapy. 1991;77(3):161–168. doi: 10.1016/S0031-9406(10)61694-X. A Review of Low Level Laser Therapy, S Kitchen MSCMCSP & C Partridge PhD; Centre for Physiotherapy Research, King’s College London Physiotherapy, Vol. 77, No. 3, March 1991 Low Level Laser Therapy: Current Clinical Practice In Northern Ireland, GD Baxter BSc, AJ Bet, MA,,JM AtienPhD, J Ravey PhD; Blamed Research Centre University Ulster Physiotherapy, Vol. 77, No. 3, March 1991 Optical Reflectance and Transmission of Tissues: Principles and Applications. Wilson B, Jaques S.; IEEE Journal of Quantum Electronics, 1990; 26:2186-2199 New Biological Phenomena Associated with Laser Radiation, M.I. Belkin & U. Schwartz; Tel-Aviv University; Health Physics, Vol. 56, No. 5, May 1989; pp. 687-690 Low-Energy Laser Therapy: Controversies & Research Findings, Jeffrey R. Basford MD; Mayo Clinic; Lasers in Surgery and Medicine 9, pp. 1-5 (1989) Mester AF, Mester A. Wound healing. Laser Therapy. 1989;1(1):7–15. Young S, Bolton P, Dyson M, Harvey W, Diamantopoulos C. Macrophage responsiveness to light therapy. Lasers in Surgery and Medicine. 1989;9:497–505. doi: 10.1002/lsm.1900090513. Effect of Helium-Neon and Infrared Laser Irradiation on Wound Healing in Rabbits, B Braverman, PhD; R McCarthy. Pharmd, A Lyankovich, MD; D Forde, BS, M Overfield, BS and M Bapna, PhD; Rush- Presbyterian-St. Luke’s Medical Center; University of Illinois, Lasers in Surgery and Medicine 9:50-58 (1989) Macrophage Responsiveness to Light Therapy, S Young PhD, P Bolton BSc, U Dyson PhD, W Harvey PhD, & C Diamantopoulos BSc; London: Lasers in Surgery and Medicine, 9; pp. 497-505 (1989) Systemic Effects of Low-Power Laser Irradiation on the Peripheral & Central Nervous System, Cutaneous Wounds & Burns, S Rochkind MD, M Rousso MD, M Nissan PhD, M Villarreal MD, L Barr-Nea PhD. & DG Rees PhD, Lasers in Surgery and Medicine, 9; pp. 174-182 (1989) Photobiology of Low-Power Laser Effects, Tina Karu PhD; Laser Technology Centre of Russia; Health Physics, Vol. 56, No. 5. May 89, pp. 691-704

, Klide AM1, Martin BB Jr., J Am Vet Med Assoc. 1989 Nov 15;195(10):1375-9. Basford JR. Low energy laser therapy: Controversies and new research findings. Lasers in Surgery and Medicine. 1989;9:1–5. doi: 10.1002/lsm.1900090103. Laser Biostimulation of Healing Wounds: Specific Effects and Mechanisms of Action, Chukuka S Enwemeka, PhD; Assistant Professor of Physical Therapy – U. of Texas, Health Science Center, San Antonio, TX; The Journal of Orthopaedic & Sports Physical Therapy, Vol. 9. No.10, 1988 Wound Management with Whirlpool and Infrared Cold Laser Treatment, P Gogia; B Hurt and T Zim; AMI-Park Plaza Hospital, Houston TX, Physical Therapy, Vol. 68, No. 8, August 1988

, Benson B. Martin VMD, Alan M. Klide, DMV, University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies-New Bolton Center, Philadelphia 19348., Vet Surg. 1987 Jan-Feb;16(1):106-10. Bone Fracture Consolidates Faster With Low-Power Laser, MA Trelles, MD and E Mayayo, MD, Barcelona, Spain; Lasers in Surgery & Med. 7:36-45 (1987) Biostimulation of Wound Healing by Lasers: Experimental Approaches in Animal Models and in Fibroblast Cultures, RP Abergel, MD; R Lyons. MD; J Castel, MS, R Dwyer. MD and i Uitlo. MD, PhD; Harbor UCLA Medical Center. CA: J Dennatol. Surgery Oncol., 13:2 Feb. 1987 The Biomedical Effects of Laser Application.Mester E, Mester AF, Mester A.; Lasers in Surgery and Medicine, 1985; 5:31-39 Kolari PJ. Penetration of unfocused laser light into the skin. Archives of Dermatological Research. 1985; 277:342–344. doi: 10.1007/BF00509097. Kaneps AJ, Hultgren BD, Riebold TW, Shires GMH. Laser therapy in the horse: Histopathological response. American Journal of Veterinary Research. 1984;45(3):581–582. Effects of Low Energy Laser on Wound Healing In a Porcine Model, J Hunter, MD; L Leonard, MD; R Wilsom MD; G Snider, MD and J D Lxon, MD; Department of Surgery, University of Utah Medical Center, Salt Lake City UT, Lasers in Surgery & Med. 3:285-290, 84 Use of Laser Light to Treat Certain Lesions in Standardbreds, L.S McKibbin DVM, & D Paraschak BSc., MA; Mod,  Veterinary Practice, March 1984, Sec. 3, p. 13 Effects of Low-Level Energy Lasers on the Healing of Full-Thickness Skin Defects, J Surinchak. MA; M Alago, BS,, R Bellamy, MD; B Stuck, MS and M Belkin, MD; Lettennan Army Institute of Research. Presidio of San Francisco, CA; Lasers in Surgery & Medicine, 2:267-274 (1983)

, Wheatley, LS McKibbin DVM, and DM Paraschak Bsc MA; Lasers in Surg &Medicine, Vol. pp. 55-59 (1983) Scc 3 Effect of Laser Rays on Wound Healing, E Mester, MD; T Spiry, MD; B Szende. MD and J Tola; Semmelweis Medical Univ. Budapest, The American Journal of Surgery. Vol 122, Oct 1971 Smith, Kendric C, The Photobiological Basis of Low Level Laser Radiation Therapy, Stanford University School of Medicine; Laser Therapy, Vol. 3, No. 1, Jan – Mar 1991

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